279868

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3771113..3771633 Replicon chromosome
Accession NZ_CP124367
Organism Escherichia coli strain AVS0465

Toxin (Protein)


Gene name ccdB Uniprot ID A0A061KX66
Locus tag QJP75_RS18300 Protein ID WP_001160964.1
Coordinates 3771349..3771633 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag QJP75_RS18295 Protein ID WP_000125566.1
Coordinates 3771113..3771346 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP75_RS18270 (3766186) 3766186..3766473 + 288 WP_000203744.1 ferredoxin-like protein FixX -
QJP75_RS18275 (3766532) 3766532..3767863 + 1332 WP_001183209.1 MFS transporter -
QJP75_RS18280 (3767971) 3767971..3768501 + 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
QJP75_RS18285 (3768494) 3768494..3770356 + 1863 WP_000377106.1 glutathione-regulated potassium-efflux system protein KefC -
QJP75_RS18290 (3770548) 3770548..3771027 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
QJP75_RS18295 (3771113) 3771113..3771346 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
QJP75_RS18300 (3771349) 3771349..3771633 + 285 WP_001160964.1 CcdB family protein Toxin
QJP75_RS18305 (3771660) 3771660..3772508 - 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
QJP75_RS18310 (3772515) 3772515..3772892 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
QJP75_RS18315 (3772895) 3772895..3773716 - 822 WP_001065365.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
QJP75_RS18320 (3773713) 3773713..3774702 - 990 WP_000241227.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
QJP75_RS18325 (3774702) 3774702..3775988 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-93)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10692.54 Da        Isoelectric Point: 10.3030

>T279868 WP_001160964.1 NZ_CP124367:3771349-3771633 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLIDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIK

Download         Length: 285 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT279868 WP_000125566.1 NZ_CP124367:3771113-3771346 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061KX66

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References