279860

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2431563..2432363 Replicon chromosome
Accession NZ_CP124367
Organism Escherichia coli strain AVS0465

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJP75_RS11930 Protein ID WP_000342452.1
Coordinates 2431563..2432090 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJP75_RS11935 Protein ID WP_001277107.1
Coordinates 2432097..2432363 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP75_RS11905 (2426639) 2426639..2427406 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
QJP75_RS11910 (2427403) 2427403..2428680 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJP75_RS11915 (2428677) 2428677..2429603 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJP75_RS11920 (2429651) 2429651..2430760 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJP75_RS11925 (2431183) 2431183..2431566 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJP75_RS11930 (2431563) 2431563..2432090 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJP75_RS11935 (2432097) 2432097..2432363 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJP75_RS11940 (2432512) 2432512..2433615 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJP75_RS11945 (2433886) 2433886..2434740 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJP75_RS11950 (2434985) 2434985..2436043 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
QJP75_RS11955 (2436036) 2436036..2436704 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T279860 WP_000342452.1 NZ_CP124367:c2432090-2431563 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT279860 WP_001277107.1 NZ_CP124367:c2432363-2432097 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References