Detailed information of TA system TA027986

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3022819..3023378
• Replicon: chromosome
• Accession: NC_018078
• Organism: Mycobacterium tuberculosis KZN 605

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: TBXG_RS14250
• Protein ID: WP_003898789.1
• Coordinates: 3023085..3023378 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: TBXG_RS14245
• Protein ID: WP_003406322.1
• Coordinates: 3022819..3023088 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TBXG_RS14235	3018081..3018869	+	789	WP_003406325.1	hypothetical protein	-
TBXG_RS14240	3019011..3022706	+	3696	WP_009938349.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
TBXG_RS14245	3022819..3023088	+	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
TBXG_RS14250	3023085..3023378	+	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
TBXG_RS14255	3023435..3024265	+	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
TBXG_RS14260	3024346..3025206	-	861	WP_003900301.1	hypothetical protein	-
TBXG_RS14265	3025386..3027074	+	1689	WP_003910308.1	PE family protein	-
TBXG_RS14270	3027097..3027528	-	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
TBXG_RS14275	3027525..3027785	-	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T27986 WP_003898789.1 NC_018078:3023085-3023378 [Mycobacterium tuberculosis KZN 605]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T27986 NC_018078:3023085-3023378 [Mycobacterium tuberculosis KZN 605]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT27986 WP_003406322.1 NC_018078:3022819-3023088 [Mycobacterium tuberculosis KZN 605]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT27986 NC_018078:3022819-3023088 [Mycobacterium tuberculosis KZN 605]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2