279857

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 1900869..1902150 Replicon chromosome
Accession NZ_CP124367
Organism Escherichia coli strain AVS0465

Toxin (Protein)


Gene name sanaT Uniprot ID A0A1X3JHM4
Locus tag QJP75_RS09305 Protein ID WP_001114681.1
Coordinates 1901257..1902150 (+) Length 298 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID V0YCI1
Locus tag QJP75_RS09300 Protein ID WP_000208383.1
Coordinates 1900869..1901264 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP75_RS09255 (1896363) 1896363..1896848 + 486 WP_282504306.1 antirestriction protein -
QJP75_RS09260 (1896864) 1896864..1897340 + 477 WP_001186727.1 RadC family protein -
QJP75_RS09265 (1897403) 1897403..1897624 + 222 WP_000692329.1 DUF987 domain-containing protein -
QJP75_RS09270 (1897643) 1897643..1898287 + 645 WP_000094916.1 hypothetical protein -
QJP75_RS09275 (1898337) 1898337..1898717 + 381 WP_001285598.1 type IV toxin-antitoxin system YeeU family antitoxin -
QJP75_RS09280 (1898794) 1898794..1899171 + 378 WP_000854689.1 TA system toxin CbtA family protein -
QJP75_RS09285 (1899168) 1899168..1899656 + 489 WP_000761699.1 DUF5983 family protein -
QJP75_RS09290 (1899673) 1899673..1899870 + 198 WP_000839293.1 DUF957 domain-containing protein -
QJP75_RS09295 (1899955) 1899955..1900800 + 846 WP_023281696.1 DUF4942 domain-containing protein -
QJP75_RS09300 (1900869) 1900869..1901264 + 396 WP_000208383.1 DUF6088 family protein Antitoxin
QJP75_RS09305 (1901257) 1901257..1902150 + 894 WP_001114681.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
QJP75_RS09310 (1902621) 1902621..1902791 + 171 Protein_1826 IS110 family transposase -
QJP75_RS09315 (1903140) 1903140..1904639 + 1500 WP_000174401.1 IS21-like element ISEc10 family transposase -
QJP75_RS09320 (1904636) 1904636..1905391 + 756 Protein_1828 IS21-like element ISEc10 family helper ATPase IstB -
QJP75_RS09325 (1906017) 1906017..1907000 + 984 WP_001296394.1 KpsF/GutQ family sugar-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(34-292)

Antitoxin

Protein of unknown function DUF6088

(10-129)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 34298.40 Da        Isoelectric Point: 5.9850

>T279857 WP_001114681.1 NZ_CP124367:1901257-1902150 [Escherichia coli]
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN

Download         Length: 894 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14608.03 Da        Isoelectric Point: 11.3150

>AT279857 WP_000208383.1 NZ_CP124367:1900869-1901264 [Escherichia coli]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3JHM4

Antitoxin

Source ID Structure
AlphaFold DB V0YCI1

References