Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1752001..1752655 Replicon chromosome
Accession NZ_CP124367
Organism Escherichia coli strain AVS0465

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QJP75_RS08495 Protein ID WP_000244765.1
Coordinates 1752001..1752408 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag QJP75_RS08500 Protein ID WP_000354050.1
Coordinates 1752389..1752655 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP75_RS08475 (1747958) 1747958..1749691 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
QJP75_RS08480 (1749697) 1749697..1750407 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJP75_RS08485 (1750432) 1750432..1751328 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QJP75_RS08490 (1751440) 1751440..1751961 + 522 WP_001055874.1 flavodoxin FldB -
QJP75_RS08495 (1752001) 1752001..1752408 - 408 WP_000244765.1 protein YgfX Toxin
QJP75_RS08500 (1752389) 1752389..1752655 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
QJP75_RS08505 (1752898) 1752898..1753878 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
QJP75_RS08510 (1753955) 1753955..1754614 - 660 WP_000250275.1 hemolysin III family protein -
QJP75_RS08515 (1754778) 1754778..1755089 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QJP75_RS08520 (1755134) 1755134..1756567 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T279855 WP_000244765.1 NZ_CP124367:c1752408-1752001 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT279855 WP_000354050.1 NZ_CP124367:c1752655-1752389 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References