Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2726462..2727078 Replicon chromosome
Accession NC_018078
Organism Mycobacterium tuberculosis KZN 605

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag TBXG_RS12925 Protein ID WP_003407593.1
Coordinates 2726462..2726779 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag TBXG_RS12930 Protein ID WP_003900349.1
Coordinates 2726776..2727078 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBXG_RS12895 2721471..2722499 - 1029 WP_003407612.1 glycosyltransferase family 2 protein -
TBXG_RS22285 2722769..2722993 + 225 WP_160522526.1 NUDIX domain-containing protein -
TBXG_RS12905 2723003..2723215 + 213 WP_003898900.1 dodecin family protein -
TBXG_RS12910 2723273..2724046 + 774 WP_003912632.1 class I SAM-dependent methyltransferase -
TBXG_RS12915 2724119..2725408 - 1290 WP_003407599.1 serine hydrolase -
TBXG_RS12920 2725461..2726465 - 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
TBXG_RS12925 2726462..2726779 - 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
TBXG_RS12930 2726776..2727078 - 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
TBXG_RS12935 2727092..2729344 - 2253 WP_003407587.1 methylmalonyl-CoA mutase -
TBXG_RS12940 2729345..2731192 - 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T27983 WP_003407593.1 NC_018078:c2726779-2726462 [Mycobacterium tuberculosis KZN 605]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T27983 NC_018078:c2726779-2726462 [Mycobacterium tuberculosis KZN 605]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT27983 WP_003900349.1 NC_018078:c2727078-2726776 [Mycobacterium tuberculosis KZN 605]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT27983 NC_018078:c2727078-2726776 [Mycobacterium tuberculosis KZN 605]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References