Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4149307..4149883 Replicon chromosome
Accession NZ_CP124357
Organism Escherichia coli strain AVS0467

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QJP58_RS20215 Protein ID WP_001297643.1
Coordinates 4149596..4149883 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag QJP58_RS20210 Protein ID WP_000063156.1
Coordinates 4149307..4149609 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP58_RS20195 (4145903) 4145903..4148053 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QJP58_RS20200 (4148103) 4148103..4148306 + 204 WP_000467859.1 YbdD/YjiX family protein -
QJP58_RS20205 (4148317) 4148317..4149273 + 957 WP_001297640.1 GTPase -
QJP58_RS20210 (4149307) 4149307..4149609 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
QJP58_RS20215 (4149596) 4149596..4149883 - 288 WP_001297643.1 BrnT family toxin Toxin
QJP58_RS20220 (4150082) 4150082..4150779 - 698 Protein_3964 IS1 family transposase -
QJP58_RS20225 (4150836) 4150836..4150931 + 96 Protein_3965 dienelactone hydrolase family protein -
QJP58_RS20230 (4151077) 4151077..4152309 + 1233 WP_001339512.1 multidrug efflux MFS transporter MdtM -
QJP58_RS20235 (4152350) 4152350..4153630 + 1281 WP_001037382.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T279823 WP_001297643.1 NZ_CP124357:c4149883-4149596 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT279823 WP_000063156.1 NZ_CP124357:c4149609-4149307 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References