Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3626774..3627392 Replicon chromosome
Accession NZ_CP124357
Organism Escherichia coli strain AVS0467

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP58_RS17740 Protein ID WP_001291435.1
Coordinates 3627174..3627392 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP58_RS17735 Protein ID WP_000344800.1
Coordinates 3626774..3627148 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP58_RS17725 (3621863) 3621863..3623056 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QJP58_RS17730 (3623079) 3623079..3626228 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP58_RS17735 (3626774) 3626774..3627148 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP58_RS17740 (3627174) 3627174..3627392 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP58_RS17745 (3627565) 3627565..3628116 + 552 WP_000102539.1 maltose O-acetyltransferase -
QJP58_RS17750 (3628232) 3628232..3628702 + 471 WP_000136192.1 YlaC family protein -
QJP58_RS17755 (3628866) 3628866..3630416 + 1551 WP_001545832.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP58_RS17760 (3630458) 3630458..3630811 - 354 WP_000878147.1 DUF1428 family protein -
QJP58_RS17770 (3631190) 3631190..3631501 + 312 WP_000409908.1 MGMT family protein -
QJP58_RS17775 (3631532) 3631532..3632104 - 573 WP_000779841.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T279820 WP_001291435.1 NZ_CP124357:3627174-3627392 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT279820 WP_000344800.1 NZ_CP124357:3626774-3627148 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References