Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2958748..2959219 Replicon chromosome
Accession NZ_CP124357
Organism Escherichia coli strain AVS0467

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QJP58_RS14530 Protein ID WP_001303511.1
Coordinates 2958941..2959219 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QJP58_RS14525 Protein ID WP_001302048.1
Coordinates 2958748..2958939 (+) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP58_RS14455 (2953815) 2953815..2953982 - 168 WP_000207997.1 hypothetical protein -
QJP58_RS14460 (2953993) 2953993..2954256 - 264 WP_000224216.1 hypothetical protein -
QJP58_RS14465 (2954258) 2954258..2954476 - 219 WP_001142588.1 DUF4014 family protein -
QJP58_RS14470 (2954478) 2954478..2954693 - 216 WP_000510387.1 hypothetical protein -
QJP58_RS14475 (2954694) 2954694..2955053 - 360 WP_001289986.1 hypothetical protein -
QJP58_RS14480 (2955050) 2955050..2955226 - 177 WP_021534704.1 hypothetical protein -
QJP58_RS14485 (2955219) 2955219..2955401 - 183 WP_001224665.1 hypothetical protein -
QJP58_RS14490 (2955530) 2955530..2955841 - 312 WP_021534703.1 hypothetical protein -
QJP58_RS14495 (2955834) 2955834..2956088 - 255 WP_000004322.1 hypothetical protein -
QJP58_RS14500 (2956085) 2956085..2956507 - 423 WP_021534702.1 DUF977 family protein -
QJP58_RS14505 (2956548) 2956548..2957510 - 963 WP_000095673.1 helix-turn-helix domain-containing protein -
QJP58_RS14510 (2957533) 2957533..2957958 - 426 WP_000693943.1 toxin YdaT family protein -
QJP58_RS14515 (2957955) 2957955..2958257 - 303 WP_000172738.1 transcriptional regulator -
QJP58_RS14520 (2958356) 2958356..2958727 + 372 WP_001169687.1 hypothetical protein -
QJP58_RS14525 (2958748) 2958748..2958939 + 192 WP_001302048.1 hypothetical protein Antitoxin
QJP58_RS14530 (2958941) 2958941..2959219 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJP58_RS14535 (2959511) 2959511..2959663 + 153 WP_000380313.1 DUF1391 family protein -
QJP58_RS14540 (2959675) 2959675..2960013 + 339 WP_000394541.1 hypothetical protein -
QJP58_RS14545 (2960002) 2960002..2960196 - 195 WP_001295058.1 hypothetical protein -
QJP58_RS14550 (2960763) 2960763..2960951 + 189 WP_000449172.1 cell division inhibition protein DicB -
QJP58_RS14555 (2960948) 2960948..2961136 + 189 WP_000199480.1 DUF1482 family protein -
QJP58_RS14560 (2961232) 2961232..2963703 + 2472 WP_032284123.1 exonuclease -
QJP58_RS14565 (2963765) 2963765..2964034 + 270 WP_000003742.1 excisionase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2940521..2968429 27908


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T279818 WP_001303511.1 NZ_CP124357:2958941-2959219 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp


Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT279818 WP_001302048.1 NZ_CP124357:2958748-2958939 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE


Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References