Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2474941..2475554 Replicon chromosome
Accession NC_018078
Organism Mycobacterium tuberculosis KZN 605

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag TBXG_RS11840 Protein ID WP_003408465.1
Coordinates 2475165..2475554 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag TBXG_RS11835 Protein ID WP_003408469.1
Coordinates 2474941..2475168 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBXG_RS11815 2470833..2471543 + 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -
TBXG_RS11820 2471533..2471952 + 420 WP_003408483.1 hypothetical protein -
TBXG_RS11825 2471995..2473242 - 1248 WP_003408476.1 serine hydrolase -
TBXG_RS11830 2473239..2474723 - 1485 WP_009937637.1 biotin carboxylase -
TBXG_RS11835 2474941..2475168 + 228 WP_003408469.1 antitoxin Antitoxin
TBXG_RS11840 2475165..2475554 + 390 WP_003408465.1 PIN domain-containing protein Toxin
TBXG_RS11855 2476164..2476943 - 780 WP_003408460.1 IclR family transcriptional regulator -
TBXG_RS11860 2476957..2477775 - 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
TBXG_RS11865 2477828..2478177 - 350 Protein_2323 cupin domain-containing protein -
TBXG_RS11870 2478177..2479007 - 831 WP_003906661.1 cyclase family protein -
TBXG_RS11875 2479010..2479924 - 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T27981 WP_003408465.1 NC_018078:2475165-2475554 [Mycobacterium tuberculosis KZN 605]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T27981 NC_018078:2475165-2475554 [Mycobacterium tuberculosis KZN 605]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT27981 WP_003408469.1 NC_018078:2474941-2475168 [Mycobacterium tuberculosis KZN 605]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT27981 NC_018078:2474941-2475168 [Mycobacterium tuberculosis KZN 605]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References