Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 139351..139994 Replicon plasmid pAVS0171-A
Accession NZ_CP124356
Organism Escherichia coli strain AVS0171

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag QJB00_RS27030 Protein ID WP_001034044.1
Coordinates 139578..139994 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1P7N7
Locus tag QJB00_RS27025 Protein ID WP_001261286.1
Coordinates 139351..139581 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB00_RS27005 (135982) 135982..136737 - 756 WP_000852146.1 replication initiation protein RepE -
QJB00_RS27010 (137459) 137459..138265 - 807 WP_000016970.1 site-specific integrase -
QJB00_RS27015 (138266) 138266..138571 - 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB -
QJB00_RS27020 (138573) 138573..138791 - 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA -
QJB00_RS27025 (139351) 139351..139581 + 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QJB00_RS27030 (139578) 139578..139994 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
QJB00_RS27035 (140069) 140069..141634 + 1566 WP_001128474.1 AAA family ATPase -
QJB00_RS27040 (141619) 141619..142641 + 1023 WP_000361402.1 helicase UvrD -
QJB00_RS27045 (143338) 143338..143339 - 2 WP_001743396.1 IS1-like element IS1A family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - senB / iutA / iutA / iutA / iutA / iutA / iucD / iucD 1..149660 149660


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15232.66 Da        Isoelectric Point: 6.8536

>T279804 WP_001034044.1 NZ_CP124356:139578-139994 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEALLKHLEQSVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAACAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8747.86 Da        Isoelectric Point: 4.3775

>AT279804 WP_001261286.1 NZ_CP124356:139351-139581 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMTEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure
AlphaFold DB A0A829CKZ6

References