Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2196851..2197539 Replicon chromosome
Accession NC_018078
Organism Mycobacterium tuberculosis KZN 605

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag TBXG_RS10510 Protein ID WP_003409958.1
Coordinates 2197120..2197539 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag TBXG_RS10505 Protein ID WP_003409968.1
Coordinates 2196851..2197111 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBXG_RS10480 2192342..2192941 - 600 WP_003409989.1 L-lysine exporter -
TBXG_RS10485 2193050..2193961 + 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
TBXG_RS10490 2194046..2194276 - 231 WP_003409980.1 DUF167 domain-containing protein -
TBXG_RS10495 2194391..2195044 + 654 WP_003409976.1 cutinase Cfp21 -
TBXG_RS10500 2195032..2196708 - 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
TBXG_RS10505 2196851..2197111 + 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
TBXG_RS10510 2197120..2197539 + 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
TBXG_RS10515 2197764..2198732 + 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
TBXG_RS10520 2198923..2199609 + 687 WP_003409954.1 immunoprotective protein Mpt64 -
TBXG_RS10525 2199788..2201233 + 1446 WP_009938446.1 APC family permease -
TBXG_RS10530 2201196..2202044 - 849 WP_003409942.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T27976 WP_003409958.1 NC_018078:2197120-2197539 [Mycobacterium tuberculosis KZN 605]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T27976 NC_018078:2197120-2197539 [Mycobacterium tuberculosis KZN 605]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT27976 WP_003409968.1 NC_018078:2196851-2197111 [Mycobacterium tuberculosis KZN 605]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT27976 NC_018078:2196851-2197111 [Mycobacterium tuberculosis KZN 605]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References