Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4331545..4332163 Replicon chromosome
Accession NZ_CP124353
Organism Escherichia coli strain AVS0226

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP71_RS21215 Protein ID WP_001291435.1
Coordinates 4331545..4331763 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP71_RS21220 Protein ID WP_000344800.1
Coordinates 4331789..4332163 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP71_RS21180 (4326832) 4326832..4327404 + 573 WP_000779831.1 YbaY family lipoprotein -
QJP71_RS21185 (4327435) 4327435..4327746 - 312 WP_000409908.1 MGMT family protein -
QJP71_RS21195 (4328125) 4328125..4328478 + 354 WP_000878135.1 DUF1428 family protein -
QJP71_RS21200 (4328520) 4328520..4330070 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP71_RS21205 (4330234) 4330234..4330704 - 471 WP_000136192.1 YlaC family protein -
QJP71_RS21210 (4330820) 4330820..4331371 - 552 WP_000102539.1 maltose O-acetyltransferase -
QJP71_RS21215 (4331545) 4331545..4331763 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP71_RS21220 (4331789) 4331789..4332163 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP71_RS21225 (4332709) 4332709..4335858 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP71_RS21230 (4335881) 4335881..4337074 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T279755 WP_001291435.1 NZ_CP124353:c4331763-4331545 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT279755 WP_000344800.1 NZ_CP124353:c4332163-4331789 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References