Detailed information of TA system TA279754

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4147167..4148856
• Replicon: chromosome
• Accession: NZ_CP124353
• Organism: Escherichia coli strain AVS0226

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP71_RS20355
• Protein ID: WP_000365807.1
• Coordinates: 4147936..4148856 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP71_RS20350
• Protein ID: WP_001295795.1
• Coordinates: 4147167..4147949 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP71_RS20345 (4143785)	4143785..4146883	-	3099	WP_000673070.1	type I restriction endonuclease	-
QJP71_RS20350 (4147167)	4147167..4147949	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP71_RS20355 (4147936)	4147936..4148856	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP71_RS20360 (4149021)	4149021..4149797	-	777	WP_282503822.1	site-specific integrase	-
QJP71_RS20365 (4150005)	4150005..4150340	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP71_RS20370 (4150567)	4150567..4150725	-	159	Protein_3985	integrase	-
QJP71_RS20375 (4150774)	4150774..4150959	+	186	WP_000146240.1	hypothetical protein	-
QJP71_RS20380 (4151174)	4151174..4151788	+	615	WP_001019923.1	YagU family protein	-
QJP71_RS20385 (4151859)	4151859..4152025	+	167	Protein_3988	tail fiber assembly protein	-
QJP71_RS20390 (4152037)	4152037..4152366	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP71_RS20395 (4152673)	4152673..4153383	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	4140917..4189072	48155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T279754 WP_000365807.1 NZ_CP124353:4147936-4148856 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT279754 WP_001295795.1 NZ_CP124353:4147167-4147949 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0