Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3386113..3386914 Replicon chromosome
Accession NZ_CP124353
Organism Escherichia coli strain AVS0226

Toxin (Protein)


Gene name yeeV Uniprot ID D8EBK0
Locus tag QJP71_RS16605 Protein ID WP_001094436.1
Coordinates 3386113..3386490 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7MN76
Locus tag QJP71_RS16610 Protein ID WP_015953067.1
Coordinates 3386537..3386914 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP71_RS16575 (3382072) 3382072..3382233 - 162 Protein_3241 DUF4942 domain-containing protein -
QJP71_RS16580 (3382324) 3382324..3383823 + 1500 WP_029700729.1 IS21-like element ISEc10 family transposase -
QJP71_RS16585 (3383820) 3383820..3384575 + 756 WP_000065240.1 IS21-like element ISEc10 family helper ATPase IstB -
QJP71_RS16590 (3384624) 3384624..3385334 - 711 WP_001621817.1 DUF4942 domain-containing protein -
QJP71_RS16595 (3385419) 3385419..3385616 - 198 WP_000839254.1 DUF957 domain-containing protein -
QJP71_RS16600 (3385628) 3385628..3386116 - 489 WP_000761714.1 DUF5983 family protein -
QJP71_RS16605 (3386113) 3386113..3386490 - 378 WP_001094436.1 TA system toxin CbtA family protein Toxin
QJP71_RS16610 (3386537) 3386537..3386914 - 378 WP_015953067.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
QJP71_RS16615 (3386993) 3386993..3387214 - 222 WP_000692312.1 DUF987 domain-containing protein -
QJP71_RS16620 (3387283) 3387283..3387759 - 477 WP_001186756.1 RadC family protein -
QJP71_RS16625 (3387774) 3387774..3388259 - 486 WP_029700724.1 antirestriction protein -
QJP71_RS16630 (3388351) 3388351..3389169 - 819 WP_001175163.1 DUF932 domain-containing protein -
QJP71_RS16635 (3389259) 3389259..3389492 - 234 WP_001278287.1 DUF905 family protein -
QJP71_RS16640 (3389498) 3389498..3390175 - 678 WP_001097301.1 hypothetical protein -
QJP71_RS16645 (3390323) 3390323..3391003 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13958.84 Da        Isoelectric Point: 6.8603

>T279749 WP_001094436.1 NZ_CP124353:c3386490-3386113 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13766.60 Da        Isoelectric Point: 6.2021

>AT279749 WP_015953067.1 NZ_CP124353:c3386914-3386537 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2L1N0

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z3CIS0

References