Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2553326..2554126 Replicon chromosome
Accession NZ_CP124353
Organism Escherichia coli strain AVS0226

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJP71_RS12785 Protein ID WP_000342452.1
Coordinates 2553326..2553853 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJP71_RS12790 Protein ID WP_001277107.1
Coordinates 2553860..2554126 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP71_RS12760 (2548402) 2548402..2549169 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
QJP71_RS12765 (2549166) 2549166..2550443 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJP71_RS12770 (2550440) 2550440..2551366 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJP71_RS12775 (2551414) 2551414..2552523 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJP71_RS12780 (2552946) 2552946..2553329 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJP71_RS12785 (2553326) 2553326..2553853 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJP71_RS12790 (2553860) 2553860..2554126 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJP71_RS12795 (2554275) 2554275..2555378 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJP71_RS12800 (2555649) 2555649..2556503 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJP71_RS12805 (2556748) 2556748..2557806 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
QJP71_RS12810 (2557799) 2557799..2558467 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T279746 WP_000342452.1 NZ_CP124353:c2553853-2553326 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT279746 WP_001277107.1 NZ_CP124353:c2554126-2553860 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References