Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 95594..96237 Replicon plasmid pAVS0362-A
Accession NZ_CP124352
Organism Escherichia coli strain AVS0362

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag QJP84_RS26765 Protein ID WP_001034044.1
Coordinates 95821..96237 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1P7N7
Locus tag QJP84_RS26760 Protein ID WP_001261286.1
Coordinates 95594..95824 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP84_RS26740 (92225) 92225..92980 - 756 WP_000852146.1 replication initiation protein RepE -
QJP84_RS26745 (93702) 93702..94508 - 807 WP_000016970.1 site-specific integrase -
QJP84_RS26750 (94509) 94509..94814 - 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB -
QJP84_RS26755 (94816) 94816..95034 - 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA -
QJP84_RS26760 (95594) 95594..95824 + 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QJP84_RS26765 (95821) 95821..96237 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
QJP84_RS26770 (96312) 96312..97877 + 1566 WP_001128474.1 AAA family ATPase -
QJP84_RS26775 (97862) 97862..98884 + 1023 WP_000361402.1 helicase UvrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - iutA / iutA / iucD 1..105909 105909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15232.66 Da        Isoelectric Point: 6.8536

>T279734 WP_001034044.1 NZ_CP124352:95821-96237 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEALLKHLEQSVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAACAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8747.86 Da        Isoelectric Point: 4.3775

>AT279734 WP_001261286.1 NZ_CP124352:95594-95824 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMTEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure
AlphaFold DB A0A829CKZ6

References