Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 94509..95034 Replicon plasmid pAVS0362-A
Accession NZ_CP124352
Organism Escherichia coli strain AVS0362

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag QJP84_RS26750 Protein ID WP_001159871.1
Coordinates 94509..94814 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H9TJP1
Locus tag QJP84_RS26755 Protein ID WP_000813630.1
Coordinates 94816..95034 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP84_RS26735 (90471) 90471..91637 - 1167 WP_000772446.1 plasmid-partitioning protein SopA -
QJP84_RS26740 (92225) 92225..92980 - 756 WP_000852146.1 replication initiation protein RepE -
QJP84_RS26745 (93702) 93702..94508 - 807 WP_000016970.1 site-specific integrase -
QJP84_RS26750 (94509) 94509..94814 - 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
QJP84_RS26755 (94816) 94816..95034 - 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
QJP84_RS26760 (95594) 95594..95824 + 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin -
QJP84_RS26765 (95821) 95821..96237 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin -
QJP84_RS26770 (96312) 96312..97877 + 1566 WP_001128474.1 AAA family ATPase -
QJP84_RS26775 (97862) 97862..98884 + 1023 WP_000361402.1 helicase UvrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - iutA / iutA / iucD 1..105909 105909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11692.49 Da        Isoelectric Point: 6.4674

>T279733 WP_001159871.1 NZ_CP124352:c94814-94509 [Escherichia coli]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8354.27 Da        Isoelectric Point: 4.5203

>AT279733 WP_000813630.1 NZ_CP124352:c95034-94816 [Escherichia coli]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTLQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CEF5

References