Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3386105..3386906 Replicon chromosome
Accession NZ_CP124351
Organism Escherichia coli strain AVS0362

Toxin (Protein)


Gene name yeeV Uniprot ID D8EBK0
Locus tag QJP84_RS16610 Protein ID WP_001094436.1
Coordinates 3386105..3386482 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7MN76
Locus tag QJP84_RS16615 Protein ID WP_015953067.1
Coordinates 3386529..3386906 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP84_RS16580 (3382064) 3382064..3382225 - 162 Protein_3242 DUF4942 domain-containing protein -
QJP84_RS16585 (3382316) 3382316..3383815 + 1500 WP_029700729.1 IS21-like element ISEc10 family transposase -
QJP84_RS16590 (3383812) 3383812..3384567 + 756 WP_000065240.1 IS21-like element ISEc10 family helper ATPase IstB -
QJP84_RS16595 (3384616) 3384616..3385326 - 711 WP_001621817.1 DUF4942 domain-containing protein -
QJP84_RS16600 (3385411) 3385411..3385608 - 198 WP_000839254.1 DUF957 domain-containing protein -
QJP84_RS16605 (3385620) 3385620..3386108 - 489 WP_000761714.1 DUF5983 family protein -
QJP84_RS16610 (3386105) 3386105..3386482 - 378 WP_001094436.1 TA system toxin CbtA family protein Toxin
QJP84_RS16615 (3386529) 3386529..3386906 - 378 WP_015953067.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
QJP84_RS16620 (3386985) 3386985..3387206 - 222 WP_000692312.1 DUF987 domain-containing protein -
QJP84_RS16625 (3387275) 3387275..3387751 - 477 WP_001186756.1 RadC family protein -
QJP84_RS16630 (3387766) 3387766..3388251 - 486 WP_029700724.1 antirestriction protein -
QJP84_RS16635 (3388343) 3388343..3389161 - 819 WP_001175163.1 DUF932 domain-containing protein -
QJP84_RS16640 (3389251) 3389251..3389484 - 234 WP_001278287.1 DUF905 family protein -
QJP84_RS16645 (3389490) 3389490..3390167 - 678 WP_001097301.1 hypothetical protein -
QJP84_RS16650 (3390315) 3390315..3390995 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13958.84 Da        Isoelectric Point: 6.8603

>T279714 WP_001094436.1 NZ_CP124351:c3386482-3386105 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13766.60 Da        Isoelectric Point: 6.2021

>AT279714 WP_015953067.1 NZ_CP124351:c3386906-3386529 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2L1N0

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z3CIS0

References