Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1890118..1890772 Replicon chromosome
Accession NZ_CP124351
Organism Escherichia coli strain AVS0362

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QJP84_RS09400 Protein ID WP_000244765.1
Coordinates 1890118..1890525 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag QJP84_RS09405 Protein ID WP_000354050.1
Coordinates 1890506..1890772 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP84_RS09380 (1886075) 1886075..1887808 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
QJP84_RS09385 (1887814) 1887814..1888524 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJP84_RS09390 (1888549) 1888549..1889445 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QJP84_RS09395 (1889557) 1889557..1890078 + 522 WP_001055874.1 flavodoxin FldB -
QJP84_RS09400 (1890118) 1890118..1890525 - 408 WP_000244765.1 protein YgfX Toxin
QJP84_RS09405 (1890506) 1890506..1890772 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
QJP84_RS09410 (1891015) 1891015..1891995 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
QJP84_RS09415 (1892072) 1892072..1892731 - 660 WP_000250275.1 hemolysin III family protein -
QJP84_RS09420 (1892895) 1892895..1893206 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QJP84_RS09425 (1893251) 1893251..1894684 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-131)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T279707 WP_000244765.1 NZ_CP124351:c1890525-1890118 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT279707 WP_000354050.1 NZ_CP124351:c1890772-1890506 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A454A7D7


Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References