Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2012571..2013100 Replicon chromosome
Accession NC_018078
Organism Mycobacterium tuberculosis KZN 605

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag TBXG_RS09600 Protein ID WP_003411124.1
Coordinates 2012783..2013100 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag TBXG_RS09595 Protein ID WP_003411127.1
Coordinates 2012571..2012786 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBXG_RS09565 2007677..2008453 + 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -
TBXG_RS09570 2008519..2009175 + 657 WP_003411133.1 cell division protein SepF -
TBXG_RS09575 2009337..2009627 + 291 WP_003900476.1 YggT family protein -
TBXG_RS09580 2009895..2010677 + 783 WP_003411131.1 cell wall synthesis protein Wag31 -
TBXG_RS09585 2010772..2011128 + 357 WP_003411130.1 hypothetical protein -
TBXG_RS09590 2011258..2012316 - 1059 WP_003411129.1 hypothetical protein -
TBXG_RS09595 2012571..2012786 + 216 WP_003411127.1 antitoxin ParD2 Antitoxin
TBXG_RS09600 2012783..2013100 + 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TBXG_RS09610 2013513..2014859 + 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
TBXG_RS09615 2014907..2015437 + 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
TBXG_RS09620 2015442..2016515 - 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
TBXG_RS09625 2016551..2016832 - 282 WP_003411112.1 hypothetical protein -
TBXG_RS09630 2016829..2017905 - 1077 WP_003411110.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T27969 WP_003411124.1 NC_018078:2012783-2013100 [Mycobacterium tuberculosis KZN 605]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T27969 NC_018078:2012783-2013100 [Mycobacterium tuberculosis KZN 605]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT27969 WP_003411127.1 NC_018078:2012571-2012786 [Mycobacterium tuberculosis KZN 605]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT27969 NC_018078:2012571-2012786 [Mycobacterium tuberculosis KZN 605]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References