Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4331643..4332261 Replicon chromosome
Accession NZ_CP124349
Organism Escherichia coli strain AVS0453

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP64_RS21225 Protein ID WP_001291435.1
Coordinates 4331643..4331861 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP64_RS21230 Protein ID WP_000344800.1
Coordinates 4331887..4332261 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP64_RS21190 (4326930) 4326930..4327502 + 573 WP_000779831.1 YbaY family lipoprotein -
QJP64_RS21195 (4327533) 4327533..4327844 - 312 WP_000409908.1 MGMT family protein -
QJP64_RS21205 (4328223) 4328223..4328576 + 354 WP_000878135.1 DUF1428 family protein -
QJP64_RS21210 (4328618) 4328618..4330168 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP64_RS21215 (4330332) 4330332..4330802 - 471 WP_000136192.1 YlaC family protein -
QJP64_RS21220 (4330918) 4330918..4331469 - 552 WP_000102539.1 maltose O-acetyltransferase -
QJP64_RS21225 (4331643) 4331643..4331861 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP64_RS21230 (4331887) 4331887..4332261 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP64_RS21235 (4332807) 4332807..4335956 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP64_RS21240 (4335979) 4335979..4337172 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T279685 WP_001291435.1 NZ_CP124349:c4331861-4331643 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT279685 WP_000344800.1 NZ_CP124349:c4332261-4331887 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References