Detailed information of TA system TA279684

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4147265..4148954
• Replicon: chromosome
• Accession: NZ_CP124349
• Organism: Escherichia coli strain AVS0453

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP64_RS20365
• Protein ID: WP_000365807.1
• Coordinates: 4148034..4148954 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP64_RS20360
• Protein ID: WP_001295795.1
• Coordinates: 4147265..4148047 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP64_RS20355 (4143883)	4143883..4146981	-	3099	WP_000673070.1	type I restriction endonuclease	-
QJP64_RS20360 (4147265)	4147265..4148047	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP64_RS20365 (4148034)	4148034..4148954	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP64_RS20370 (4149119)	4149119..4149895	-	777	WP_282503822.1	site-specific integrase	-
QJP64_RS20375 (4150103)	4150103..4150438	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP64_RS20380 (4150665)	4150665..4150823	-	159	Protein_3986	integrase	-
QJP64_RS20385 (4150872)	4150872..4151057	+	186	WP_000146240.1	hypothetical protein	-
QJP64_RS20390 (4151272)	4151272..4151886	+	615	WP_001019923.1	YagU family protein	-
QJP64_RS20395 (4151957)	4151957..4152123	+	167	Protein_3989	tail fiber assembly protein	-
QJP64_RS20400 (4152135)	4152135..4152464	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP64_RS20405 (4152771)	4152771..4153481	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	4141015..4189170	48155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T279684 WP_000365807.1 NZ_CP124349:4148034-4148954 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT279684 WP_001295795.1 NZ_CP124349:4147265-4148047 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0