Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2963090..2963561 Replicon chromosome
Accession NZ_CP124347
Organism Escherichia coli strain AVS0283

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QJP56_RS14605 Protein ID WP_001303511.1
Coordinates 2963283..2963561 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QJP56_RS14600 Protein ID WP_001302048.1
Coordinates 2963090..2963281 (+) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP56_RS14530 (2958157) 2958157..2958324 - 168 WP_000207997.1 hypothetical protein -
QJP56_RS14535 (2958335) 2958335..2958598 - 264 WP_000224216.1 hypothetical protein -
QJP56_RS14540 (2958600) 2958600..2958818 - 219 WP_001142588.1 DUF4014 family protein -
QJP56_RS14545 (2958820) 2958820..2959035 - 216 WP_000510387.1 hypothetical protein -
QJP56_RS14550 (2959036) 2959036..2959395 - 360 WP_001289986.1 hypothetical protein -
QJP56_RS14555 (2959392) 2959392..2959568 - 177 WP_021534704.1 hypothetical protein -
QJP56_RS14560 (2959561) 2959561..2959743 - 183 WP_001224665.1 hypothetical protein -
QJP56_RS14565 (2959872) 2959872..2960183 - 312 WP_021534703.1 hypothetical protein -
QJP56_RS14570 (2960176) 2960176..2960430 - 255 WP_000004322.1 hypothetical protein -
QJP56_RS14575 (2960427) 2960427..2960849 - 423 WP_021534702.1 DUF977 family protein -
QJP56_RS14580 (2960890) 2960890..2961852 - 963 WP_000095673.1 helix-turn-helix domain-containing protein -
QJP56_RS14585 (2961875) 2961875..2962300 - 426 WP_000693943.1 toxin YdaT family protein -
QJP56_RS14590 (2962297) 2962297..2962599 - 303 WP_000172738.1 transcriptional regulator -
QJP56_RS14595 (2962698) 2962698..2963069 + 372 WP_001169687.1 hypothetical protein -
QJP56_RS14600 (2963090) 2963090..2963281 + 192 WP_001302048.1 hypothetical protein Antitoxin
QJP56_RS14605 (2963283) 2963283..2963561 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJP56_RS14610 (2963853) 2963853..2964005 + 153 WP_000380313.1 DUF1391 family protein -
QJP56_RS14615 (2964017) 2964017..2964355 + 339 WP_000394541.1 hypothetical protein -
QJP56_RS14620 (2964344) 2964344..2964538 - 195 WP_001295058.1 hypothetical protein -
QJP56_RS14625 (2965105) 2965105..2965293 + 189 WP_000449172.1 cell division inhibition protein DicB -
QJP56_RS14630 (2965290) 2965290..2965478 + 189 WP_000199480.1 DUF1482 family protein -
QJP56_RS14635 (2965574) 2965574..2968045 + 2472 WP_032284123.1 exonuclease -
QJP56_RS14640 (2968107) 2968107..2968376 + 270 WP_000003742.1 excisionase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2944863..2972771 27908
- inside Prophage sitABCD - 2855854..2976631 120777


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T279656 WP_001303511.1 NZ_CP124347:2963283-2963561 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp


Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT279656 WP_001302048.1 NZ_CP124347:2963090-2963281 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE


Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References