Detailed information of TA system TA279637

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3816719..3818408
• Replicon: chromosome
• Accession: NZ_CP124345
• Organism: Escherichia coli strain AVS0530

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP77_RS18670
• Protein ID: WP_000365807.1
• Coordinates: 3816719..3817639 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP77_RS18675
• Protein ID: WP_001295795.1
• Coordinates: 3817626..3818408 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP77_RS18630 (3812192)	3812192..3812902	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QJP77_RS18635 (3813209)	3813209..3813538	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP77_RS18640 (3813550)	3813550..3813716	-	167	Protein_3661	tail fiber assembly protein	-
QJP77_RS18645 (3813787)	3813787..3814401	-	615	WP_001019923.1	YagU family protein	-
QJP77_RS18650 (3814616)	3814616..3814801	-	186	WP_000146240.1	hypothetical protein	-
QJP77_RS18655 (3814850)	3814850..3815008	+	159	Protein_3664	integrase	-
QJP77_RS18660 (3815235)	3815235..3815570	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP77_RS18665 (3815778)	3815778..3816554	+	777	WP_000171155.1	site-specific integrase	-
QJP77_RS18670 (3816719)	3816719..3817639	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP77_RS18675 (3817626)	3817626..3818408	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP77_RS18680 (3818692)	3818692..3821790	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3775729..3825471	49742

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T279637 WP_000365807.1 NZ_CP124345:c3817639-3816719 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT279637 WP_001295795.1 NZ_CP124345:c3818408-3817626 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0