Detailed information of TA system TA279615

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3816844..3818533
• Replicon: chromosome
• Accession: NZ_CP124343
• Organism: Escherichia coli strain AVS0533

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP85_RS18685
• Protein ID: WP_000365807.1
• Coordinates: 3816844..3817764 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP85_RS18690
• Protein ID: WP_001295795.1
• Coordinates: 3817751..3818533 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP85_RS18645 (3812317)	3812317..3813027	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QJP85_RS18650 (3813334)	3813334..3813663	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP85_RS18655 (3813675)	3813675..3813841	-	167	Protein_3661	tail fiber assembly protein	-
QJP85_RS18660 (3813912)	3813912..3814526	-	615	WP_001019923.1	YagU family protein	-
QJP85_RS18665 (3814741)	3814741..3814926	-	186	WP_000146240.1	hypothetical protein	-
QJP85_RS18670 (3814975)	3814975..3815133	+	159	Protein_3664	integrase	-
QJP85_RS18675 (3815360)	3815360..3815695	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP85_RS18680 (3815903)	3815903..3816679	+	777	WP_000171155.1	site-specific integrase	-
QJP85_RS18685 (3816844)	3816844..3817764	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP85_RS18690 (3817751)	3817751..3818533	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP85_RS18695 (3818817)	3818817..3821915	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3775854..3825596	49742

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T279615 WP_000365807.1 NZ_CP124343:c3817764-3816844 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT279615 WP_001295795.1 NZ_CP124343:c3818533-3817751 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0