Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3632778..3633396 Replicon chromosome
Accession NZ_CP124343
Organism Escherichia coli strain AVS0533

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP85_RS17820 Protein ID WP_001291435.1
Coordinates 3633178..3633396 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP85_RS17815 Protein ID WP_000344800.1
Coordinates 3632778..3633152 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP85_RS17805 (3627867) 3627867..3629060 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QJP85_RS17810 (3629083) 3629083..3632232 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP85_RS17815 (3632778) 3632778..3633152 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP85_RS17820 (3633178) 3633178..3633396 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP85_RS17825 (3633569) 3633569..3634120 + 552 WP_000102539.1 maltose O-acetyltransferase -
QJP85_RS17830 (3634236) 3634236..3634706 + 471 WP_000136192.1 YlaC family protein -
QJP85_RS17835 (3634870) 3634870..3636420 + 1551 WP_001545832.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP85_RS17840 (3636462) 3636462..3636815 - 354 WP_000878147.1 DUF1428 family protein -
QJP85_RS17850 (3637194) 3637194..3637505 + 312 WP_000409908.1 MGMT family protein -
QJP85_RS17855 (3637536) 3637536..3638108 - 573 WP_000779841.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T279614 WP_001291435.1 NZ_CP124343:3633178-3633396 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT279614 WP_000344800.1 NZ_CP124343:3632778-3633152 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References