Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4125240..4125816 Replicon chromosome
Accession NZ_CP124341
Organism Escherichia coli strain AVS0710

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QJB06_RS20120 Protein ID WP_001297643.1
Coordinates 4125529..4125816 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag QJB06_RS20115 Protein ID WP_000063156.1
Coordinates 4125240..4125542 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB06_RS20100 (4121836) 4121836..4123986 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QJB06_RS20105 (4124036) 4124036..4124239 + 204 WP_000467859.1 YbdD/YjiX family protein -
QJB06_RS20110 (4124250) 4124250..4125206 + 957 WP_001297640.1 GTPase -
QJB06_RS20115 (4125240) 4125240..4125542 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
QJB06_RS20120 (4125529) 4125529..4125816 - 288 WP_001297643.1 BrnT family toxin Toxin
QJB06_RS20125 (4126015) 4126015..4126712 - 698 Protein_3949 IS1 family transposase -
QJB06_RS20130 (4126769) 4126769..4126864 + 96 Protein_3950 dienelactone hydrolase family protein -
QJB06_RS20135 (4127010) 4127010..4128242 + 1233 WP_001339512.1 multidrug efflux MFS transporter MdtM -
QJB06_RS20140 (4128283) 4128283..4129563 + 1281 WP_001037382.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T279595 WP_001297643.1 NZ_CP124341:c4125816-4125529 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT279595 WP_000063156.1 NZ_CP124341:c4125542-4125240 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References