Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4015765..4016315 Replicon chromosome
Accession NZ_CP124341
Organism Escherichia coli strain AVS0710

Toxin (Protein)


Gene name ccdB Uniprot ID S1PDG4
Locus tag QJB06_RS19590 Protein ID WP_001160966.1
Coordinates 4015765..4016079 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag QJB06_RS19595 Protein ID WP_000125566.1
Coordinates 4016082..4016315 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB06_RS19565 (4011440) 4011440..4012726 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
QJB06_RS19570 (4012726) 4012726..4013715 + 990 WP_000241227.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
QJB06_RS19575 (4013712) 4013712..4014533 + 822 WP_001065363.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
QJB06_RS19580 (4014536) 4014536..4014913 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
QJB06_RS19585 (4014920) 4014920..4015768 + 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
QJB06_RS19590 (4015765) 4015765..4016079 - 315 WP_001160966.1 CcdB family protein Toxin
QJB06_RS19595 (4016082) 4016082..4016315 - 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
QJB06_RS19600 (4016401) 4016401..4016880 - 480 WP_000624375.1 type 3 dihydrofolate reductase -
QJB06_RS19605 (4017072) 4017072..4018934 - 1863 WP_000377124.1 glutathione-regulated potassium-efflux system protein KefC -
QJB06_RS19610 (4018927) 4018927..4019457 - 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
QJB06_RS19615 (4019565) 4019565..4020896 - 1332 WP_001183207.1 MFS transporter -
QJB06_RS19620 (4020955) 4020955..4021242 - 288 WP_000203741.1 ferredoxin-like protein FixX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.72 Da        Isoelectric Point: 9.0851

>T279594 WP_001160966.1 NZ_CP124341:c4016079-4015765 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT279594 WP_000125566.1 NZ_CP124341:c4016315-4016082 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G815

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References