Detailed information of TA system TA279593

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3787670..3789359
• Replicon: chromosome
• Accession: NZ_CP124341
• Organism: Escherichia coli strain AVS0710

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJB06_RS18535
• Protein ID: WP_000365807.1
• Coordinates: 3787670..3788590 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJB06_RS18540
• Protein ID: WP_001295795.1
• Coordinates: 3788577..3789359 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJB06_RS18495 (3783143)	3783143..3783853	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QJB06_RS18500 (3784160)	3784160..3784489	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJB06_RS18505 (3784501)	3784501..3784667	-	167	Protein_3634	tail fiber assembly protein	-
QJB06_RS18510 (3784738)	3784738..3785352	-	615	WP_001019923.1	YagU family protein	-
QJB06_RS18515 (3785567)	3785567..3785752	-	186	WP_000146240.1	hypothetical protein	-
QJB06_RS18520 (3785801)	3785801..3785959	+	159	Protein_3637	integrase	-
QJB06_RS18525 (3786186)	3786186..3786521	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJB06_RS18530 (3786729)	3786729..3787505	+	777	WP_000171155.1	site-specific integrase	-
QJB06_RS18535 (3787670)	3787670..3788590	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJB06_RS18540 (3788577)	3788577..3789359	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJB06_RS18545 (3789643)	3789643..3792741	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3746680..3796422	49742

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T279593 WP_000365807.1 NZ_CP124341:c3788590-3787670 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT279593 WP_001295795.1 NZ_CP124341:c3789359-3788577 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0