Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2936265..2936736 Replicon chromosome
Accession NZ_CP124341
Organism Escherichia coli strain AVS0710

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QJB06_RS14465 Protein ID WP_001303511.1
Coordinates 2936458..2936736 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QJB06_RS14460 Protein ID WP_001302048.1
Coordinates 2936265..2936456 (+) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB06_RS14390 (2931332) 2931332..2931499 - 168 WP_000207997.1 hypothetical protein -
QJB06_RS14395 (2931510) 2931510..2931773 - 264 WP_000224216.1 hypothetical protein -
QJB06_RS14400 (2931775) 2931775..2931993 - 219 WP_001142588.1 DUF4014 family protein -
QJB06_RS14405 (2931995) 2931995..2932210 - 216 WP_000510387.1 hypothetical protein -
QJB06_RS14410 (2932211) 2932211..2932570 - 360 WP_001289986.1 hypothetical protein -
QJB06_RS14415 (2932567) 2932567..2932743 - 177 WP_021534704.1 hypothetical protein -
QJB06_RS14420 (2932736) 2932736..2932918 - 183 WP_001224665.1 hypothetical protein -
QJB06_RS14425 (2933047) 2933047..2933358 - 312 WP_021534703.1 hypothetical protein -
QJB06_RS14430 (2933351) 2933351..2933605 - 255 WP_000004322.1 hypothetical protein -
QJB06_RS14435 (2933602) 2933602..2934024 - 423 WP_021534702.1 DUF977 family protein -
QJB06_RS14440 (2934065) 2934065..2935027 - 963 WP_000095673.1 helix-turn-helix domain-containing protein -
QJB06_RS14445 (2935050) 2935050..2935475 - 426 WP_000693943.1 toxin YdaT family protein -
QJB06_RS14450 (2935472) 2935472..2935774 - 303 WP_000172738.1 transcriptional regulator -
QJB06_RS14455 (2935873) 2935873..2936244 + 372 WP_001169687.1 hypothetical protein -
QJB06_RS14460 (2936265) 2936265..2936456 + 192 WP_001302048.1 hypothetical protein Antitoxin
QJB06_RS14465 (2936458) 2936458..2936736 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJB06_RS14470 (2937028) 2937028..2937180 + 153 WP_000380313.1 DUF1391 family protein -
QJB06_RS14475 (2937192) 2937192..2937530 + 339 WP_000394541.1 hypothetical protein -
QJB06_RS14480 (2937519) 2937519..2937713 - 195 WP_001295058.1 hypothetical protein -
QJB06_RS14485 (2938280) 2938280..2938468 + 189 WP_000449172.1 cell division inhibition protein DicB -
QJB06_RS14490 (2938465) 2938465..2938653 + 189 WP_000199480.1 DUF1482 family protein -
QJB06_RS14495 (2938749) 2938749..2941220 + 2472 WP_032284123.1 exonuclease -
QJB06_RS14500 (2941282) 2941282..2941551 + 270 WP_000003742.1 excisionase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2890418..2949806 59388
- inside Prophage sitABCD - 2829029..2949806 120777


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T279590 WP_001303511.1 NZ_CP124341:2936458-2936736 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp


Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT279590 WP_001302048.1 NZ_CP124341:2936265-2936456 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE


Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References