Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 949038..949692 Replicon chromosome
Accession NZ_CP124341
Organism Escherichia coli strain AVS0710

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QJB06_RS04690 Protein ID WP_000244765.1
Coordinates 949285..949692 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag QJB06_RS04685 Protein ID WP_000354050.1
Coordinates 949038..949304 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB06_RS04665 (945126) 945126..946559 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
QJB06_RS04670 (946604) 946604..946915 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QJB06_RS04675 (947079) 947079..947738 + 660 WP_000250275.1 hemolysin III family protein -
QJB06_RS04680 (947815) 947815..948795 - 981 WP_000886080.1 tRNA-modifying protein YgfZ -
QJB06_RS04685 (949038) 949038..949304 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
QJB06_RS04690 (949285) 949285..949692 + 408 WP_000244765.1 protein YgfX Toxin
QJB06_RS04695 (949732) 949732..950253 - 522 WP_001055874.1 flavodoxin FldB -
QJB06_RS04700 (950365) 950365..951261 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QJB06_RS04705 (951286) 951286..951996 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJB06_RS04710 (952002) 952002..953735 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T279582 WP_000244765.1 NZ_CP124341:949285-949692 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT279582 WP_000354050.1 NZ_CP124341:949038-949304 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References