Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4155446..4156022 Replicon chromosome
Accession NZ_CP124339
Organism Escherichia coli strain AVS0713

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QJP93_RS20275 Protein ID WP_001297643.1
Coordinates 4155735..4156022 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag QJP93_RS20270 Protein ID WP_000063156.1
Coordinates 4155446..4155748 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP93_RS20255 (4152042) 4152042..4154192 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QJP93_RS20260 (4154242) 4154242..4154445 + 204 WP_000467859.1 YbdD/YjiX family protein -
QJP93_RS20265 (4154456) 4154456..4155412 + 957 WP_001297640.1 GTPase -
QJP93_RS20270 (4155446) 4155446..4155748 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
QJP93_RS20275 (4155735) 4155735..4156022 - 288 WP_001297643.1 BrnT family toxin Toxin
QJP93_RS20280 (4156221) 4156221..4156918 - 698 Protein_3980 IS1 family transposase -
QJP93_RS20285 (4156975) 4156975..4157070 + 96 Protein_3981 dienelactone hydrolase family protein -
QJP93_RS20290 (4157216) 4157216..4158448 + 1233 WP_001339512.1 multidrug efflux MFS transporter MdtM -
QJP93_RS20295 (4158489) 4158489..4159769 + 1281 WP_001037382.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T279573 WP_001297643.1 NZ_CP124339:c4156022-4155735 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT279573 WP_000063156.1 NZ_CP124339:c4155748-4155446 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References