Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 1276715..1277319 Replicon chromosome
Accession NC_018078
Organism Mycobacterium tuberculosis KZN 605

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag TBXG_RS05930 Protein ID WP_003414492.1
Coordinates 1276927..1277319 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A829CBY8
Locus tag TBXG_RS05925 Protein ID WP_003414495.1
Coordinates 1276715..1276930 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBXG_RS05900 1271717..1272628 + 912 WP_003414505.1 sugar ABC transporter permease -
TBXG_RS05905 1272625..1273452 + 828 WP_003414504.1 carbohydrate ABC transporter permease -
TBXG_RS05910 1273455..1274765 + 1311 WP_003414501.1 ABC transporter substrate-binding protein -
TBXG_RS05915 1274758..1275840 + 1083 WP_003414499.1 ABC transporter ATP-binding protein -
TBXG_RS05920 1275919..1276668 - 750 WP_003414497.1 enoyl-CoA hydratase -
TBXG_RS05925 1276715..1276930 + 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
TBXG_RS05930 1276927..1277319 + 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin Toxin
TBXG_RS05935 1277340..1277609 + 270 WP_003414489.1 DUF2277 family protein -
TBXG_RS05940 1277606..1278151 + 546 WP_009939112.1 DUF1802 family protein -
TBXG_RS05945 1278456..1279343 + 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin -
TBXG_RS05950 1279346..1280230 + 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
TBXG_RS05955 1280502..1281047 + 546 WP_003913758.1 DUF1802 family protein -
TBXG_RS05960 1281381..1282169 + 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T27957 WP_003414492.1 NC_018078:1276927-1277319 [Mycobacterium tuberculosis KZN 605]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

>T27957 NC_018078:1276927-1277319 [Mycobacterium tuberculosis KZN 605]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7511.55 Da        Isoelectric Point: 4.9732

>AT27957 WP_003414495.1 NC_018078:1276715-1276930 [Mycobacterium tuberculosis KZN 605]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS

Download         Length: 216 bp

>AT27957 NC_018078:1276715-1276930 [Mycobacterium tuberculosis KZN 605]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BWM8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CBY8

References