Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2964509..2964980 Replicon chromosome
Accession NZ_CP124339
Organism Escherichia coli strain AVS0713

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QJP93_RS14600 Protein ID WP_001303511.1
Coordinates 2964702..2964980 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QJP93_RS14595 Protein ID WP_001302048.1
Coordinates 2964509..2964700 (+) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP93_RS14525 (2959576) 2959576..2959743 - 168 WP_000207997.1 hypothetical protein -
QJP93_RS14530 (2959754) 2959754..2960017 - 264 WP_000224216.1 hypothetical protein -
QJP93_RS14535 (2960019) 2960019..2960237 - 219 WP_001142588.1 DUF4014 family protein -
QJP93_RS14540 (2960239) 2960239..2960454 - 216 WP_000510387.1 hypothetical protein -
QJP93_RS14545 (2960455) 2960455..2960814 - 360 WP_001289986.1 hypothetical protein -
QJP93_RS14550 (2960811) 2960811..2960987 - 177 WP_021534704.1 hypothetical protein -
QJP93_RS14555 (2960980) 2960980..2961162 - 183 WP_001224665.1 hypothetical protein -
QJP93_RS14560 (2961291) 2961291..2961602 - 312 WP_021534703.1 hypothetical protein -
QJP93_RS14565 (2961595) 2961595..2961849 - 255 WP_000004322.1 hypothetical protein -
QJP93_RS14570 (2961846) 2961846..2962268 - 423 WP_021534702.1 DUF977 family protein -
QJP93_RS14575 (2962309) 2962309..2963271 - 963 WP_000095673.1 helix-turn-helix domain-containing protein -
QJP93_RS14580 (2963294) 2963294..2963719 - 426 WP_000693943.1 toxin YdaT family protein -
QJP93_RS14585 (2963716) 2963716..2964018 - 303 WP_000172738.1 transcriptional regulator -
QJP93_RS14590 (2964117) 2964117..2964488 + 372 WP_001169687.1 hypothetical protein -
QJP93_RS14595 (2964509) 2964509..2964700 + 192 WP_001302048.1 hypothetical protein Antitoxin
QJP93_RS14600 (2964702) 2964702..2964980 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJP93_RS14605 (2965272) 2965272..2965424 + 153 WP_000380313.1 DUF1391 family protein -
QJP93_RS14610 (2965436) 2965436..2965774 + 339 WP_000394541.1 hypothetical protein -
QJP93_RS14615 (2965763) 2965763..2965957 - 195 WP_001295058.1 hypothetical protein -
QJP93_RS14620 (2966524) 2966524..2966712 + 189 WP_000449172.1 cell division inhibition protein DicB -
QJP93_RS14625 (2966709) 2966709..2966897 + 189 WP_000199480.1 DUF1482 family protein -
QJP93_RS14630 (2966993) 2966993..2969464 + 2472 WP_032284123.1 exonuclease -
QJP93_RS14635 (2969526) 2969526..2969795 + 270 WP_000003742.1 excisionase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2946282..2974190 27908


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T279568 WP_001303511.1 NZ_CP124339:2964702-2964980 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp


Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT279568 WP_001302048.1 NZ_CP124339:2964509-2964700 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE


Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References