Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1235854..1236402 Replicon chromosome
Accession NC_018078
Organism Mycobacterium tuberculosis KZN 605

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag TBXG_RS05730 Protein ID WP_003414602.1
Coordinates 1235854..1236117 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag TBXG_RS05735 Protein ID WP_003414599.1
Coordinates 1236121..1236402 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBXG_RS05710 1230928..1232169 + 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
TBXG_RS05715 1232177..1233391 + 1215 WP_003899518.1 zinc metalloprotease Rip -
TBXG_RS05720 1233408..1234571 + 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
TBXG_RS05725 1234627..1235481 + 855 WP_003899516.1 GNAT family N-acetyltransferase -
TBXG_RS05730 1235854..1236117 - 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TBXG_RS05735 1236121..1236402 - 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
TBXG_RS05740 1236674..1238485 + 1812 WP_003906921.1 penicillin-binding protein -
TBXG_RS05745 1238567..1238947 - 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
TBXG_RS05750 1238944..1239192 - 249 WP_003913411.1 antitoxin VapB23 -
TBXG_RS05755 1239296..1239880 + 585 WP_003899514.1 DUF1707 domain-containing protein -
TBXG_RS05760 1239922..1240779 + 858 WP_003899513.1 type I methionyl aminopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T27956 WP_003414602.1 NC_018078:c1236117-1235854 [Mycobacterium tuberculosis KZN 605]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T27956 NC_018078:c1236117-1235854 [Mycobacterium tuberculosis KZN 605]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT27956 WP_003414599.1 NC_018078:c1236402-1236121 [Mycobacterium tuberculosis KZN 605]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT27956 NC_018078:c1236402-1236121 [Mycobacterium tuberculosis KZN 605]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References