Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4137060..4137636 Replicon chromosome
Accession NZ_CP124337
Organism Escherichia coli strain AVS0971

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QJP90_RS20165 Protein ID WP_001297643.1
Coordinates 4137349..4137636 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag QJP90_RS20160 Protein ID WP_000063156.1
Coordinates 4137060..4137362 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP90_RS20145 (4133656) 4133656..4135806 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QJP90_RS20150 (4135856) 4135856..4136059 + 204 WP_000467859.1 YbdD/YjiX family protein -
QJP90_RS20155 (4136070) 4136070..4137026 + 957 WP_001297640.1 GTPase -
QJP90_RS20160 (4137060) 4137060..4137362 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
QJP90_RS20165 (4137349) 4137349..4137636 - 288 WP_001297643.1 BrnT family toxin Toxin
QJP90_RS20170 (4137835) 4137835..4138532 - 698 Protein_3956 IS1 family transposase -
QJP90_RS20175 (4138589) 4138589..4138684 + 96 Protein_3957 dienelactone hydrolase family protein -
QJP90_RS20180 (4138830) 4138830..4140062 + 1233 WP_001339512.1 multidrug efflux MFS transporter MdtM -
QJP90_RS20185 (4140103) 4140103..4141383 + 1281 WP_001037382.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T279551 WP_001297643.1 NZ_CP124337:c4137636-4137349 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT279551 WP_000063156.1 NZ_CP124337:c4137362-4137060 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References