Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1230114..1230801 Replicon chromosome
Accession NC_018078
Organism Mycobacterium tuberculosis KZN 605

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag TBXG_RS05700 Protein ID WP_003414624.1
Coordinates 1230114..1230557 (-) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag TBXG_RS05705 Protein ID WP_003414620.1
Coordinates 1230544..1230801 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBXG_RS05675 1225962..1226228 - 267 WP_015456449.1 DUF2631 domain-containing protein -
TBXG_RS05680 1226328..1226909 - 582 WP_003414644.1 fasciclin domain-containing protein -
TBXG_RS05685 1227005..1228753 - 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
TBXG_RS05690 1229085..1229276 - 192 WP_003414632.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
TBXG_RS05695 1229372..1230034 - 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
TBXG_RS05700 1230114..1230557 - 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
TBXG_RS05705 1230544..1230801 - 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
TBXG_RS05710 1230928..1232169 + 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
TBXG_RS05715 1232177..1233391 + 1215 WP_003899518.1 zinc metalloprotease Rip -
TBXG_RS05720 1233408..1234571 + 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
TBXG_RS05725 1234627..1235481 + 855 WP_003899516.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T27955 WP_003414624.1 NC_018078:c1230557-1230114 [Mycobacterium tuberculosis KZN 605]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

>T27955 NC_018078:c1230557-1230114 [Mycobacterium tuberculosis KZN 605]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT27955 WP_003414620.1 NC_018078:c1230801-1230544 [Mycobacterium tuberculosis KZN 605]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp

>AT27955 NC_018078:c1230801-1230544 [Mycobacterium tuberculosis KZN 605]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References