Detailed information of TA system TA279549

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3798052..3799741
• Replicon: chromosome
• Accession: NZ_CP124337
• Organism: Escherichia coli strain AVS0971

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP90_RS18560
• Protein ID: WP_000365807.1
• Coordinates: 3798052..3798972 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP90_RS18565
• Protein ID: WP_001295795.1
• Coordinates: 3798959..3799741 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP90_RS18520 (3793525)	3793525..3794235	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QJP90_RS18525 (3794542)	3794542..3794871	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP90_RS18530 (3794883)	3794883..3795049	-	167	Protein_3637	tail fiber assembly protein	-
QJP90_RS18535 (3795120)	3795120..3795734	-	615	WP_001019923.1	YagU family protein	-
QJP90_RS18540 (3795949)	3795949..3796134	-	186	WP_000146240.1	hypothetical protein	-
QJP90_RS18545 (3796183)	3796183..3796341	+	159	Protein_3640	integrase	-
QJP90_RS18550 (3796568)	3796568..3796903	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP90_RS18555 (3797111)	3797111..3797887	+	777	WP_000171155.1	site-specific integrase	-
QJP90_RS18560 (3798052)	3798052..3798972	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP90_RS18565 (3798959)	3798959..3799741	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP90_RS18570 (3800025)	3800025..3803123	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3757839..3806804	48965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T279549 WP_000365807.1 NZ_CP124337:c3798972-3798052 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT279549 WP_001295795.1 NZ_CP124337:c3799741-3798959 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0