Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2946738..2947209 Replicon chromosome
Accession NZ_CP124337
Organism Escherichia coli strain AVS0971

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QJP90_RS14490 Protein ID WP_001303511.1
Coordinates 2946931..2947209 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QJP90_RS14485 Protein ID WP_001302048.1
Coordinates 2946738..2946929 (+) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP90_RS14415 (2941805) 2941805..2941972 - 168 WP_000207997.1 hypothetical protein -
QJP90_RS14420 (2941983) 2941983..2942246 - 264 WP_000224216.1 hypothetical protein -
QJP90_RS14425 (2942248) 2942248..2942466 - 219 WP_001142588.1 DUF4014 family protein -
QJP90_RS14430 (2942468) 2942468..2942683 - 216 WP_000510387.1 hypothetical protein -
QJP90_RS14435 (2942684) 2942684..2943043 - 360 WP_001289986.1 hypothetical protein -
QJP90_RS14440 (2943040) 2943040..2943216 - 177 WP_021534704.1 hypothetical protein -
QJP90_RS14445 (2943209) 2943209..2943391 - 183 WP_001224665.1 hypothetical protein -
QJP90_RS14450 (2943520) 2943520..2943831 - 312 WP_021534703.1 hypothetical protein -
QJP90_RS14455 (2943824) 2943824..2944078 - 255 WP_000004322.1 hypothetical protein -
QJP90_RS14460 (2944075) 2944075..2944497 - 423 WP_021534702.1 DUF977 family protein -
QJP90_RS14465 (2944538) 2944538..2945500 - 963 WP_000095673.1 helix-turn-helix domain-containing protein -
QJP90_RS14470 (2945523) 2945523..2945948 - 426 WP_000693943.1 toxin YdaT family protein -
QJP90_RS14475 (2945945) 2945945..2946247 - 303 WP_000172738.1 transcriptional regulator -
QJP90_RS14480 (2946346) 2946346..2946717 + 372 WP_001169687.1 hypothetical protein -
QJP90_RS14485 (2946738) 2946738..2946929 + 192 WP_001302048.1 hypothetical protein Antitoxin
QJP90_RS14490 (2946931) 2946931..2947209 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJP90_RS14495 (2947501) 2947501..2947653 + 153 WP_000380313.1 DUF1391 family protein -
QJP90_RS14500 (2947665) 2947665..2948003 + 339 WP_000394541.1 hypothetical protein -
QJP90_RS14505 (2947992) 2947992..2948186 - 195 WP_001295058.1 hypothetical protein -
QJP90_RS14510 (2948753) 2948753..2948941 + 189 WP_000449172.1 cell division inhibition protein DicB -
QJP90_RS14515 (2948938) 2948938..2949126 + 189 WP_000199480.1 DUF1482 family protein -
QJP90_RS14520 (2949222) 2949222..2951693 + 2472 WP_032284123.1 exonuclease -
QJP90_RS14525 (2951755) 2951755..2952024 + 270 WP_000003742.1 excisionase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage sitABCD - 2839502..2960279 120777
- inside Prophage - - 2900891..2960279 59388
- inside Prophage sitABCD - 2832841..2960279 127438


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T279546 WP_001303511.1 NZ_CP124337:2946931-2947209 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp


Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT279546 WP_001302048.1 NZ_CP124337:2946738-2946929 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE


Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References