Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3933606..3934260 Replicon chromosome
Accession NZ_CP124334
Organism Escherichia coli strain AVS0786

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QJP89_RS19295 Protein ID WP_000244765.1
Coordinates 3933853..3934260 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag QJP89_RS19290 Protein ID WP_000354050.1
Coordinates 3933606..3933872 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP89_RS19270 (3929694) 3929694..3931127 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
QJP89_RS19275 (3931172) 3931172..3931483 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QJP89_RS19280 (3931647) 3931647..3932306 + 660 WP_000250275.1 hemolysin III family protein -
QJP89_RS19285 (3932383) 3932383..3933363 - 981 WP_000886080.1 tRNA-modifying protein YgfZ -
QJP89_RS19290 (3933606) 3933606..3933872 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
QJP89_RS19295 (3933853) 3933853..3934260 + 408 WP_000244765.1 protein YgfX Toxin
QJP89_RS19300 (3934300) 3934300..3934821 - 522 WP_001055874.1 flavodoxin FldB -
QJP89_RS19305 (3934933) 3934933..3935829 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QJP89_RS19310 (3935854) 3935854..3936564 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJP89_RS19315 (3936570) 3936570..3938303 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T279530 WP_000244765.1 NZ_CP124334:3933853-3934260 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT279530 WP_000354050.1 NZ_CP124334:3933606-3933872 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References