Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 3248616..3249416 Replicon chromosome
Accession NZ_CP124334
Organism Escherichia coli strain AVS0786

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJP89_RS15830 Protein ID WP_000342452.1
Coordinates 3248889..3249416 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJP89_RS15825 Protein ID WP_001277107.1
Coordinates 3248616..3248882 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP89_RS15805 (3244275) 3244275..3244943 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
QJP89_RS15810 (3244936) 3244936..3245994 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
QJP89_RS15815 (3246239) 3246239..3247093 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJP89_RS15820 (3247364) 3247364..3248467 + 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJP89_RS15825 (3248616) 3248616..3248882 + 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJP89_RS15830 (3248889) 3248889..3249416 + 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJP89_RS15835 (3249413) 3249413..3249796 - 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJP89_RS15840 (3250219) 3250219..3251328 + 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJP89_RS15845 (3251376) 3251376..3252302 + 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJP89_RS15850 (3252299) 3252299..3253576 + 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJP89_RS15855 (3253573) 3253573..3254340 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T279526 WP_000342452.1 NZ_CP124334:3248889-3249416 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT279526 WP_001277107.1 NZ_CP124334:3248616-3248882 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References