Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 2416980..2417477 Replicon chromosome
Accession NZ_CP124334
Organism Escherichia coli strain AVS0786

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QJP89_RS12025 Protein ID WP_001173343.1
Coordinates 2416980..2417153 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag QJP89_RS12030 Protein ID WP_001312331.1
Coordinates 2417181..2417477 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP89_RS12015 (2413650) 2413650..2415107 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
QJP89_RS12020 (2415344) 2415344..2416861 + 1518 WP_000003806.1 lysine--tRNA ligase -
QJP89_RS12025 (2416980) 2416980..2417153 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QJP89_RS12030 (2417181) 2417181..2417477 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QJP89_RS12035 (2417705) 2417705..2417977 - 273 WP_000405643.1 GNAT family N-acetyltransferase -
QJP89_RS12040 (2418191) 2418191..2422120 - 3930 WP_001080127.1 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2392237..2433160 40923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T279524 WP_001173343.1 NZ_CP124334:c2417153-2416980 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT279524 WP_001312331.1 NZ_CP124334:c2417477-2417181 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References