Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 2018068..2018644 Replicon chromosome
Accession NZ_CP124334
Organism Escherichia coli strain AVS0786

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QJP89_RS10070 Protein ID WP_001297643.1
Coordinates 2018357..2018644 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag QJP89_RS10065 Protein ID WP_000063156.1
Coordinates 2018068..2018370 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP89_RS10050 (2014664) 2014664..2016814 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QJP89_RS10055 (2016864) 2016864..2017067 + 204 WP_000467859.1 YbdD/YjiX family protein -
QJP89_RS10060 (2017078) 2017078..2018034 + 957 WP_001297640.1 GTPase -
QJP89_RS10065 (2018068) 2018068..2018370 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
QJP89_RS10070 (2018357) 2018357..2018644 - 288 WP_001297643.1 BrnT family toxin Toxin
QJP89_RS10075 (2018843) 2018843..2019540 - 698 Protein_1979 IS1 family transposase -
QJP89_RS10080 (2019597) 2019597..2019692 + 96 Protein_1980 dienelactone hydrolase family protein -
QJP89_RS10085 (2019838) 2019838..2021070 + 1233 WP_001339512.1 multidrug efflux MFS transporter MdtM -
QJP89_RS10090 (2021111) 2021111..2022391 + 1281 WP_001037382.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T279521 WP_001297643.1 NZ_CP124334:c2018644-2018357 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT279521 WP_000063156.1 NZ_CP124334:c2018370-2018068 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References