Detailed information of TA system TA279519

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1679060..1680749
• Replicon: chromosome
• Accession: NZ_CP124334
• Organism: Escherichia coli strain AVS0786

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP89_RS08465
• Protein ID: WP_000365807.1
• Coordinates: 1679060..1679980 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP89_RS08470
• Protein ID: WP_001295795.1
• Coordinates: 1679967..1680749 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP89_RS08425 (1674533)	1674533..1675243	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QJP89_RS08430 (1675550)	1675550..1675879	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP89_RS08435 (1675891)	1675891..1676057	-	167	Protein_1660	tail fiber assembly protein	-
QJP89_RS08440 (1676128)	1676128..1676742	-	615	WP_001019923.1	YagU family protein	-
QJP89_RS08445 (1676957)	1676957..1677142	-	186	WP_000146240.1	hypothetical protein	-
QJP89_RS08450 (1677191)	1677191..1677349	+	159	Protein_1663	integrase	-
QJP89_RS08455 (1677576)	1677576..1677911	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP89_RS08460 (1678119)	1678119..1678895	+	777	WP_000171155.1	site-specific integrase	-
QJP89_RS08465 (1679060)	1679060..1679980	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP89_RS08470 (1679967)	1679967..1680749	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP89_RS08475 (1681033)	1681033..1684131	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	1638847..1687812	48965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T279519 WP_000365807.1 NZ_CP124334:c1679980-1679060 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT279519 WP_001295795.1 NZ_CP124334:c1680749-1679967 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0