Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1495771..1496389 Replicon chromosome
Accession NZ_CP124334
Organism Escherichia coli strain AVS0786

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP89_RS07605 Protein ID WP_001291435.1
Coordinates 1496171..1496389 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP89_RS07600 Protein ID WP_000344800.1
Coordinates 1495771..1496145 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP89_RS07590 (1490860) 1490860..1492053 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QJP89_RS07595 (1492076) 1492076..1495225 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP89_RS07600 (1495771) 1495771..1496145 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP89_RS07605 (1496171) 1496171..1496389 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP89_RS07610 (1496562) 1496562..1497113 + 552 WP_000102539.1 maltose O-acetyltransferase -
QJP89_RS07615 (1497229) 1497229..1497699 + 471 WP_000136192.1 YlaC family protein -
QJP89_RS07620 (1497863) 1497863..1499413 + 1551 WP_001545832.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP89_RS07625 (1499455) 1499455..1499808 - 354 WP_000878147.1 DUF1428 family protein -
QJP89_RS07635 (1500187) 1500187..1500498 + 312 WP_000409908.1 MGMT family protein -
QJP89_RS07640 (1500529) 1500529..1501101 - 573 WP_000779841.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T279518 WP_001291435.1 NZ_CP124334:1496171-1496389 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT279518 WP_000344800.1 NZ_CP124334:1495771-1496145 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References