Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4331770..4332388 Replicon chromosome
Accession NZ_CP124332
Organism Escherichia coli strain AVS0753

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJP82_RS21235 Protein ID WP_001291435.1
Coordinates 4331770..4331988 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJP82_RS21240 Protein ID WP_000344800.1
Coordinates 4332014..4332388 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP82_RS21200 (4327057) 4327057..4327629 + 573 WP_000779831.1 YbaY family lipoprotein -
QJP82_RS21205 (4327660) 4327660..4327971 - 312 WP_000409908.1 MGMT family protein -
QJP82_RS21215 (4328350) 4328350..4328703 + 354 WP_000878135.1 DUF1428 family protein -
QJP82_RS21220 (4328745) 4328745..4330295 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJP82_RS21225 (4330459) 4330459..4330929 - 471 WP_000136192.1 YlaC family protein -
QJP82_RS21230 (4331045) 4331045..4331596 - 552 WP_000102539.1 maltose O-acetyltransferase -
QJP82_RS21235 (4331770) 4331770..4331988 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QJP82_RS21240 (4332014) 4332014..4332388 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJP82_RS21245 (4332934) 4332934..4336083 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJP82_RS21250 (4336106) 4336106..4337299 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T279497 WP_001291435.1 NZ_CP124332:c4331988-4331770 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT279497 WP_000344800.1 NZ_CP124332:c4332388-4332014 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References