Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2553681..2554481 Replicon chromosome
Accession NZ_CP124332
Organism Escherichia coli strain AVS0753

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJP82_RS12805 Protein ID WP_000342452.1
Coordinates 2553681..2554208 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJP82_RS12810 Protein ID WP_001277107.1
Coordinates 2554215..2554481 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP82_RS12780 (2548757) 2548757..2549524 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
QJP82_RS12785 (2549521) 2549521..2550798 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJP82_RS12790 (2550795) 2550795..2551721 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJP82_RS12795 (2551769) 2551769..2552878 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJP82_RS12800 (2553301) 2553301..2553684 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJP82_RS12805 (2553681) 2553681..2554208 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJP82_RS12810 (2554215) 2554215..2554481 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJP82_RS12815 (2554630) 2554630..2555733 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJP82_RS12820 (2556004) 2556004..2556858 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJP82_RS12825 (2557103) 2557103..2558161 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
QJP82_RS12830 (2558154) 2558154..2558822 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T279488 WP_000342452.1 NZ_CP124332:c2554208-2553681 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT279488 WP_001277107.1 NZ_CP124332:c2554481-2554215 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References