Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1890475..1891129 Replicon chromosome
Accession NZ_CP124332
Organism Escherichia coli strain AVS0753

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QJP82_RS09420 Protein ID WP_000244765.1
Coordinates 1890475..1890882 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag QJP82_RS09425 Protein ID WP_000354050.1
Coordinates 1890863..1891129 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP82_RS09400 (1886432) 1886432..1888165 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
QJP82_RS09405 (1888171) 1888171..1888881 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJP82_RS09410 (1888906) 1888906..1889802 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QJP82_RS09415 (1889914) 1889914..1890435 + 522 WP_001055874.1 flavodoxin FldB -
QJP82_RS09420 (1890475) 1890475..1890882 - 408 WP_000244765.1 protein YgfX Toxin
QJP82_RS09425 (1890863) 1890863..1891129 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
QJP82_RS09430 (1891372) 1891372..1892352 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
QJP82_RS09435 (1892429) 1892429..1893088 - 660 WP_000250275.1 hemolysin III family protein -
QJP82_RS09440 (1893252) 1893252..1893563 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QJP82_RS09445 (1893608) 1893608..1895041 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T279484 WP_000244765.1 NZ_CP124332:c1890882-1890475 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT279484 WP_000354050.1 NZ_CP124332:c1891129-1890863 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References