Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1771..2318 Replicon plasmid pAVS0787-B
Accession NZ_CP124330
Organism Escherichia coli strain AVS0787

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag QJP62_RS27055 Protein ID WP_250110461.1
Coordinates 2040..2318 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A8B4NDS9
Locus tag QJP62_RS27050 Protein ID WP_033802255.1
Coordinates 1771..2040 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP62_RS27045 (1) 1..858 + 858 WP_125093756.1 incFII family plasmid replication initiator RepA -
QJP62_RS27050 (1771) 1771..2040 + 270 WP_033802255.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QJP62_RS27055 (2040) 2040..2318 + 279 WP_250110461.1 type II toxin-antitoxin system toxin YacB Toxin
QJP62_RS27060 (2641) 2641..3219 + 579 WP_235802409.1 hypothetical protein -
QJP62_RS27065 (3573) 3573..3908 - 336 WP_001340323.1 hypothetical protein -
QJP62_RS27070 (4246) 4246..5226 + 981 WP_033807854.1 plasmid segregation protein ParM -
QJP62_RS27075 (5229) 5229..5651 + 423 WP_000774832.1 plasmid partitioning/stability family protein -
QJP62_RS27080 (5675) 5675..5965 + 291 WP_236743670.1 hypothetical protein -
QJP62_RS27085 (6075) 6075..6977 + 903 WP_282517447.1 DUF1281 domain-containing protein -
QJP62_RS27090 (6974) 6974..7285 + 312 WP_249821863.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..61165 61165


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10790.43 Da        Isoelectric Point: 8.4615

>T279472 WP_250110461.1 NZ_CP124330:2040-2318 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSVSSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10360.73 Da        Isoelectric Point: 7.2055

>AT279472 WP_033802255.1 NZ_CP124330:1771-2040 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQFERGDVLPHDMVEFSAAAWRD
EMSRKIADK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4NDS9

References